Hyperbaric oxygen therapy otherwise known as HBOT has proven to be an effective therapy to improve the progress of lots of diseases especially hypoxia-related injuries and has been clinically established as a wide-used therapy for patients with carbon monoxide poisoning, decompression sickness, arterial gas embolism, problematic wounds, and so on. As far as the liver is concerned HBOT was (in most studies) positively evaluated as a potential therapeutic option for liver transplantation, acute liver injury, nonalcoholic steatohepatitis, fibrosis, and cancer, especially for hepatic artery thrombosis. However, some controversies are existed, possibly due to hyperbaric oxygen toxicity. This study summarizes the current understandings of the role of HBOT in liver diseases and hepatic regeneration.
